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KMID : 1138520150180030068
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Journal of Pharmacopuncture
2015 Volume.18 No. 3 p.68 ~ p.74
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Taurine Regulates Mitochondrial Function During 7,12-Dimethyl Benz[a]anthracene Induced Experimental Mammary Carcinogenesis
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Vanitha Manickam Kalappan
Priya Kalpana Deepa
Baskaran Kuppusamy
Periyasamy Kuppusamy
Saravanan Dhravidamani
Venkateswari Ramachandran
Mani Balasundaram Revathi
Ilakkia Aruldass
Selvaraj Sundaramoorthy
Menaka Rajendran
Geetha Mahendran
Rashanthy Nadarajah
Anandakumar Pandi
Sakthisekaran Dhanapal
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Abstract
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Objectives: The present study was undertaken to determine the modulatory effect of taurine on the liver mitochondrial enzyme system with reference to mitochondrial lipid peroxidation (LPO), antioxidants, major tricarboxylic acid cycle enzymes, and electron transport chain enzymes during 7,12-dimethyl benz[a]anthracene (DMBA) induced breast cancer in Sprague-Dawley rats.
Methods: Animals in which breast cancer had been induced by using DMBA (25 mg/kg body weight) showed an increase in mitochondrial LPO together with decreases in enzymic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST)), non-enzymic antioxidants (reduced glutathione (GSH), vitamin C, and vitamin E), in citric acid cycle enzymes (isocitrate dehydrogenase (ICDH), alpha ketoglutarate dehydrogenase (alpha KDH), succinate dehydrogenase (SDH) and malate dehydrogenase (MDH)), and in electron transport chain (ETC) complexes.
Results: Taurine (100 mg/kg body weight) treatment decreased liver mitochondrial LPO and augmented the activities/levels of enzymic, and non-enzymic antioxidants, tricarboxylic acid cycle enzymes and ETC complexes.
Conclusion: The results of our present study demonstrated the chemotherapeutic efficacy of taurine treatment for DMBA-induced breast carcinomas.
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KEYWORD
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breast cancer, electron transport chain complexes, mitochondrial lipid peroxidation, mitochondrial antioxidant, taurine, tricarboxylic acid cycle enzymes
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